St. John's wort is an herb commonly used in Europe for decades and more recently the topic
of scientific investigation in this country. St. John's wort has been found more effective than
placebo and equally as effective as tricyclic antidepressants in the short-term management
of mild-tomoderate depression. Comparisons to selective serotonin reuptake inhibitors have
provided equivocal data. While it is generally well tolerated in clinical use, there is
accumulating evidence of significant interactions with drugs. This evidence-based …