Statins decrease programmed death-ligand 1 (PD-L1) by inhibiting AKT and β-catenin signaling
Retrospective observational studies have reported that statins improve clinical outcomes in
patients previously treated with programmed cell death protein 1 (PD-1)-targeting
monoclonal antibodies for malignant pleural mesothelioma (MPM) and advanced non-small
cell lung cancer (NSCLC). In multiple mouse cancer models, de novo synthesis of
mevalonate and cholesterol inhibitors was found to synergize with anti-PD-1 antibody
therapy. In the present study, we investigated whether statins affect programmed death …
patients previously treated with programmed cell death protein 1 (PD-1)-targeting
monoclonal antibodies for malignant pleural mesothelioma (MPM) and advanced non-small
cell lung cancer (NSCLC). In multiple mouse cancer models, de novo synthesis of
mevalonate and cholesterol inhibitors was found to synergize with anti-PD-1 antibody
therapy. In the present study, we investigated whether statins affect programmed death …
[引用][C] Statin Decrease Programmed Death-Ligand (PD-L1) by Inhibiting AKT and β-Catenin Signaling
LIM Chang-Hoon, F Xue-Quan… - 한국생물공학회학술 …, 2023 - dbpia.co.kr
Retrospective observational studies have reported that statins improve clinical outcomes in
patients previously treated with programmed cell death protein 1 (PD-1) targeting
monoclonal antibodies for malignant pleural mesothelioma (MPM) and advanced non-small-
cell lung cancer (NSCLC). In multiple mouse cancer models, de novosynthesis of
mevalonate and cholesterol inhibitors was found to synergize with anti-PD-1 antibody
therapy. In the present study, we investigated whether statins affect programmed death …
patients previously treated with programmed cell death protein 1 (PD-1) targeting
monoclonal antibodies for malignant pleural mesothelioma (MPM) and advanced non-small-
cell lung cancer (NSCLC). In multiple mouse cancer models, de novosynthesis of
mevalonate and cholesterol inhibitors was found to synergize with anti-PD-1 antibody
therapy. In the present study, we investigated whether statins affect programmed death …
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