Stevens-Johnson syndrome is a rare, severe and life-threatening condition that develops mostly in response to drug use. We present a case of Stevens-Johnson syndrome in a boy of 11 years old, most probably developed in response to a combination of etiologic factors, such as virus infection, use of ibuprofen, and topical use of sulfanilamide agents. The clinical picture of the child was suggestive, involving tunica mucosa of mouth, genitals, conjunctiva, and skin. Parenteral administration of glucocorticoids, detoxification, antibiotic prophylaxis, and topical treatment led to rapid regression of clinical symptoms and prevented the development of complications. The treatment of Stevens-Johnson syndrome involves systemic glucocorticoids in combination with topical therapy. In our patient, the treatment avoided serious complications and led to rapid regression of cutaneous manifestations. The etiology of Stevens-Johnson syndrome is sometimes difficult to establish. Physicians should avoid polypragmasia and