Stimuli‐Responsive Cycloaurated “OFF‐ON” Switchable Anion Transporters
Angewandte Chemie International Edition, 2020•Wiley Online Library
Anion transporters have shown potential application as anti‐cancer agents that function by
disrupting homeostasis and triggering cell death. In this research article we report
switchable anion transport by gold complexes of anion transporters that are “switched on” in
situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in
higher concentrations in tumors than in healthy tissue and hence this approach offers a
strategy to target these systems to tumors.
disrupting homeostasis and triggering cell death. In this research article we report
switchable anion transport by gold complexes of anion transporters that are “switched on” in
situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in
higher concentrations in tumors than in healthy tissue and hence this approach offers a
strategy to target these systems to tumors.
Abstract
Anion transporters have shown potential application as anti‐cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.
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