Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
CD28 costimulation is required for the generation of naturally derived regulatory T cells
(nTregs) in the thymus through lymphocyte-specific protein tyrosine kinase (Lck) signaling.
However, it is not clear how CD28 costimulation regulates the generation of induced Tregs
(iTregs) from naive CD4 T-cell precursors in the periphery. To address this question, we
induced iTregs (CD25+ Foxp3+) from naive CD4 T cells (CD25− Foxp3−) by T-cell receptor
stimulation with additional transforming growth factorβ (TGFβ) in vitro, and found that the …
(nTregs) in the thymus through lymphocyte-specific protein tyrosine kinase (Lck) signaling.
However, it is not clear how CD28 costimulation regulates the generation of induced Tregs
(iTregs) from naive CD4 T-cell precursors in the periphery. To address this question, we
induced iTregs (CD25+ Foxp3+) from naive CD4 T cells (CD25− Foxp3−) by T-cell receptor
stimulation with additional transforming growth factorβ (TGFβ) in vitro, and found that the …
Strong CD28 Costimulation Suppresses Induction of Regulatory T Cells From Naïve Precursors through Lck Signaling.
Abstract 3728 CD28 costimulation is required for the generation of naturally-derived
regulatory T cells (nTregs) in the thymus through Lck-signaling. However, it is not clear how
CD28 costimulation regulates the generation of induced Tregs (iTregs) from naïve CD4 T-
cell precursors in the periphery. To address this question, we induced iTregs (CD25+
Foxp3+) from naïve CD4 T cells (CD25− Foxp3−) by TCR-stimulation with additional TGFβ
in vitro, and found that the generation of iTregs was inversely related to the level of CD28 …
regulatory T cells (nTregs) in the thymus through Lck-signaling. However, it is not clear how
CD28 costimulation regulates the generation of induced Tregs (iTregs) from naïve CD4 T-
cell precursors in the periphery. To address this question, we induced iTregs (CD25+
Foxp3+) from naïve CD4 T cells (CD25− Foxp3−) by TCR-stimulation with additional TGFβ
in vitro, and found that the generation of iTregs was inversely related to the level of CD28 …