Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships
The DNA-binding activity of the eukaryotic transcription factor Ets-1 (E26 avian
erythroblastosis virus oncogene-Etwenty-six) is negatively regulated by inhibitory regions
that flank the ETS domain. Based on the results of solution studies, these N-and C-terminal
inhibitory regions have been proposed to pack against the ETS domain and form an
autoinhibitory module whose N terminus partially unfolds upon binding of Ets-1 to DNA.
Mutations that disrupt autoinhibition of DNA binding also cause a structural change in the …
erythroblastosis virus oncogene-Etwenty-six) is negatively regulated by inhibitory regions
that flank the ETS domain. Based on the results of solution studies, these N-and C-terminal
inhibitory regions have been proposed to pack against the ETS domain and form an
autoinhibitory module whose N terminus partially unfolds upon binding of Ets-1 to DNA.
Mutations that disrupt autoinhibition of DNA binding also cause a structural change in the …
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