Structural analysis of the hexasome, lacking one histone H2A/H2B dimer from the conventional nucleosome
Y Arimura, H Tachiwana, T Oda, M Sato… - Biochemistry, 2012 - ACS Publications
Genomic DNA is packaged into chromatin in eukaryotes, and the nucleosome is the
fundamental unit of chromatin. The canonical nucleosome is the octasome, which is
composed of two H2A/H2B dimers and two H3/H4 dimers. During transcription elongation,
one of the H2A/H2B dimers is removed from the octasome. The depletion of the H2A/H2B
dimer is also suggested to occur during DNA replication and repair. The remaining histone
components are believed to maintain a nucleosomal structure called a “hexasome”, which is …
fundamental unit of chromatin. The canonical nucleosome is the octasome, which is
composed of two H2A/H2B dimers and two H3/H4 dimers. During transcription elongation,
one of the H2A/H2B dimers is removed from the octasome. The depletion of the H2A/H2B
dimer is also suggested to occur during DNA replication and repair. The remaining histone
components are believed to maintain a nucleosomal structure called a “hexasome”, which is …