Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine …

ML Barta, K Thomas, H Yuan, S Lovell… - Journal of Biological …, 2014 - ASBMB
The obligate intracellular human pathogen Chlamydia trachomatis is the etiological agent of
blinding trachoma and sexually transmitted disease. Genomic sequencing of Chlamydia
indicated this medically important bacterium was not exclusively dependent on the host cell
for energy. In order for the electron transport chain to function, electron shuttling between
membrane-embedded complexes requires lipid-soluble quinones (eg menaquionone or
ubiquinone). The sources or biosynthetic pathways required to obtain these electron carriers …
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