Structural and functional analysis of a potent sarbecovirus neutralizing antibody
SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19
pandemic that has resulted in more than one million infections and 73,000 deaths,. Vaccine
and therapeutic discovery efforts are paramount to curb the pandemic spread of this
zoonotic virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is
the main target of neutralizing antibodies. Here we describe multiple monoclonal antibodies
targeting SARS-CoV-2 S identified from memory B cells of a SARS survivor infected in 2003 …
pandemic that has resulted in more than one million infections and 73,000 deaths,. Vaccine
and therapeutic discovery efforts are paramount to curb the pandemic spread of this
zoonotic virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is
the main target of neutralizing antibodies. Here we describe multiple monoclonal antibodies
targeting SARS-CoV-2 S identified from memory B cells of a SARS survivor infected in 2003 …
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