Structural and functional characterization of Streptomyces plicatus β-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis
We have sequenced the Streptomyces plicatus β-N-acetylhexosaminidase (SpHex) gene
and identified the encoded protein as a member of family 20 glycosyl hydrolases. This family
includes human β-N-acetylhexosaminidases whose deficiency results in various forms of G
M2 gangliosidosis. Based upon the x-ray structure of Serratia marcescens chitobiase
(SmChb), we generated a three-dimensional model ofSpHex by comparative molecular
modeling. The overall structure of the enzyme is very similar to homology modeling-derived …
and identified the encoded protein as a member of family 20 glycosyl hydrolases. This family
includes human β-N-acetylhexosaminidases whose deficiency results in various forms of G
M2 gangliosidosis. Based upon the x-ray structure of Serratia marcescens chitobiase
(SmChb), we generated a three-dimensional model ofSpHex by comparative molecular
modeling. The overall structure of the enzyme is very similar to homology modeling-derived …
以上显示的是最相近的搜索结果。 查看全部搜索结果