Structural and functional profiling of the lateral gate of the Sec61 translocon
JH Reithinger, C Yim, S Kim, H Lee, H Kim - Journal of Biological Chemistry, 2014 - ASBMB
The evolutionarily conserved Sec61 translocon mediates the translocation and membrane
insertion of proteins. For the integration of proteins into the membrane, the Sec61 translocon
opens laterally to the lipid bilayer. Previous studies suggest that the lateral opening of the
channel is mediated by the helices TM2b and TM7 of a pore-forming subunit of the Sec61
translocon. To map key residues in TM2b and TM7 in yeast Sec61 that modulate lateral
gating activity, we performed alanine scanning and in vivo site-directed photocross-linking …
insertion of proteins. For the integration of proteins into the membrane, the Sec61 translocon
opens laterally to the lipid bilayer. Previous studies suggest that the lateral opening of the
channel is mediated by the helices TM2b and TM7 of a pore-forming subunit of the Sec61
translocon. To map key residues in TM2b and TM7 in yeast Sec61 that modulate lateral
gating activity, we performed alanine scanning and in vivo site-directed photocross-linking …
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