Structural and thermodynamic basis of proline-induced transmembrane complex stabilization
T Schmidt, AJ Situ, TS Ulmer - Scientific reports, 2016 - nature.com
In membrane proteins, proline-mediated helix kinks are indispensable for the tight packing
of transmembrane (TM) helices. However, kinks invariably affect numerous interhelical
interactions, questioning the acceptance of proline substitutions and evolutionary origin of
kinks. Here, we present the structural and thermodynamic basis of proline-induced integrin
αIIbβ3 TM complex stabilization to understand the introduction of proline kinks in membrane
proteins. In phospholipid bicelles, the A711P substitution in the center of the β3 TM helix …
of transmembrane (TM) helices. However, kinks invariably affect numerous interhelical
interactions, questioning the acceptance of proline substitutions and evolutionary origin of
kinks. Here, we present the structural and thermodynamic basis of proline-induced integrin
αIIbβ3 TM complex stabilization to understand the introduction of proline kinks in membrane
proteins. In phospholipid bicelles, the A711P substitution in the center of the β3 TM helix …
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