Structural basis for CD4+ T cell epitope dominance in arbo-flavivirus envelope proteins: a meta-analysis
Viral Immunology, 2017•liebertpub.com
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein
(E protein) immunogenicity that can be explained by the likelihood of epitope processing, as
determined by E protein three-dimensional structures. Differential processing may be at
least partially responsible for variations in disease severity among arbo-flaviruses and
points to structural features that modulate protection from disease.
(E protein) immunogenicity that can be explained by the likelihood of epitope processing, as
determined by E protein three-dimensional structures. Differential processing may be at
least partially responsible for variations in disease severity among arbo-flaviruses and
points to structural features that modulate protection from disease.
Abstract
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.
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