Structural basis for the unique biological function of small GTPase RHEB
The small GTPase Rheb displays unique biological and biochemical properties different
from other small GTPases and functions as an important mediator between the tumor
suppressor proteins TSC1 and TSC2 and the mammalian target of rapamycin to stimulate
cell growth. We report here the three-dimensional structures of human Rheb in complexes
with GDP, GTP, and GppNHp (5′-(β, γ-imide) triphosphate), which reveal novel structural
features of Rheb and provide a molecular basis for its distinct properties. During GTP/GDP …
from other small GTPases and functions as an important mediator between the tumor
suppressor proteins TSC1 and TSC2 and the mammalian target of rapamycin to stimulate
cell growth. We report here the three-dimensional structures of human Rheb in complexes
with GDP, GTP, and GppNHp (5′-(β, γ-imide) triphosphate), which reveal novel structural
features of Rheb and provide a molecular basis for its distinct properties. During GTP/GDP …
以上显示的是最相近的搜索结果。 查看全部搜索结果