Structural basis of substrate recognition and catalysis by fucosyltransferase 8
Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an
important step in the maturation of complex and hybrid N-glycans. This simple modification
can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant
to understanding the invasiveness of some cancers, development of mAb therapeutics, and
the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of
FUT8 are well-characterized and provide a framework for understanding N-glycan …
important step in the maturation of complex and hybrid N-glycans. This simple modification
can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant
to understanding the invasiveness of some cancers, development of mAb therapeutics, and
the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of
FUT8 are well-characterized and provide a framework for understanding N-glycan …
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