Structural characterization of interaction between human ubiquitin-specific protease 7 and immediate-early protein ICP0 of herpes simplex virus-1
AK Pozhidaeva, KN Mohni, S Dhe-Paganon… - Journal of Biological …, 2015 - ASBMB
Human ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that prevents
protein degradation by removing polyubiquitin chains from its substrates. It regulates the
stability of a number of human transcription factors and tumor suppressors and plays a
critical role in the development of several types of cancer, including prostate and small cell
lung cancer. In addition, human USP7 is targeted by several viruses of the Herpesviridae
family and is required for effective herpesvirus infection. The USP7 C-terminal region (C …
protein degradation by removing polyubiquitin chains from its substrates. It regulates the
stability of a number of human transcription factors and tumor suppressors and plays a
critical role in the development of several types of cancer, including prostate and small cell
lung cancer. In addition, human USP7 is targeted by several viruses of the Herpesviridae
family and is required for effective herpesvirus infection. The USP7 C-terminal region (C …