RIG-I and MDA5 are cytoplasmic DEX (D/H) helicase proteins that can induce signaling in
response to RNA ligands, including those from viral infections. LGP2, a homolog of RIG-I
and MDA5 without the caspase recruitment domain required for signaling, plays an
important role in modulating signaling by MDA5 and RIG-I, presumably through
heterocomplex formation and/or by serving as a sink for RNAs. Here we demonstrate that …