Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design
Abstract First identified in The Netherlands in 2004, human coronavirus NL63 (HCoV-NL63)
was found to cause worldwide infections. Patients infected by HCoV-NL63 are typically
young children with upper and lower respiratory tract infection, presenting with symptoms
including croup, bronchiolitis and pneumonia. Unfortunately, there are currently no effective
antiviral therapy to contain HCoV-NL63 infection. CoV genomes encode an integral viral
component, main protease (Mpro), which is essential for viral replication through proteolytic …
was found to cause worldwide infections. Patients infected by HCoV-NL63 are typically
young children with upper and lower respiratory tract infection, presenting with symptoms
including croup, bronchiolitis and pneumonia. Unfortunately, there are currently no effective
antiviral therapy to contain HCoV-NL63 infection. CoV genomes encode an integral viral
component, main protease (Mpro), which is essential for viral replication through proteolytic …