The qualitative analysis for structural robustness study subjected to severe earthquakes is unable to meet engineering requirements, and a quantitative analysis method for structural robustness is needed to be proposed. The existing analysis methods, such as Incremental Dynamic Analysis Method and Pushover method, only study the response of the structure directly from the macroscopic view, rather than focusing on the response of a single component on the structure. Especially for the construction of isolated structure, the impact of accidental bearing failure on the isolated structure and the impact of progressive collapse cannot be considered. In this paper, based on the Alternative Load Path Method, the quantitative analysis method for structural robustness analysis under earthquake is proposed. The structural robustness of some different vertical irregular isolated structures under different earthquakes is studied.