The present study was designed to study the effect of propolis and beeswax powder on hepatic rats. Forty-eight adult male albino rats were used in this study, their weighting were (150±10g) divided into eight groups, sex rats each. One of them they were kept as a positive control–ve group, while the other seven groups were injected by Carbon Tetrachloride (CCl4) to induce liver disorder. One of them was kept as a control (+) group and the other six groups treated with propolis, beeswax and mixture of them at concentrations 2.5% and 5% from the main diet. Serum lipid profiles [total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), high-density lipoprotein (HDL-c)], glucose levels, catalase (CAT) enzyme, superoxide dismutase (SOD) enzyme, liver enzyme activities (ALT, AST, and ALP), and kidney functions (creatinine, uric acid, and urea levels) were measured at the end of experiment. From the obtained results it could be concluded that feeding rats on propolis and bees wax at 5% level caused significant (P≤ 0.05) increase in HDL-c, catalase (CAT) and superoxide dismutase (SOD) enzymes, but with significant (P≤ 0.05) decreases in liver functions, kidney functions, lipid profile, serum glucose and malonaldehyde enzyme as compared with control (+ ve) group, which reflects the powerful nutraceutical therapeutic effect for feeding on propolis and bees wax for improving the biochemical parameters which detected in liver illnesses.