… of 2’-modified antisense oligonucleotides that act via an … the properties of the resulting
oligonucleotides. These topics … of chemical modification at the 2’-position of the sugar which …

… of synthetic oligonucleotides that contain backbone, base, andsugar modifications to investigate
… the applications of synthetic oligonucleotides that contain backbone, base, and sugar …

… In conclusion, we have presented preliminary data on or-DNA, the first sugar modified
Chimeric … Among all the possible CNA, we presume that sugar modified CNA (and we are not …

… impact of chemical modifications on the sugar puckering and conformational dynamics of
the nucleosides and oligonucleotides. We have classified the sugar modifications based on the …

… To fully characterize the antiproliferative activity of G-rich oligonucleotides such as GRO29A,
we have examined several analogues with modified sugar−phosphate backbones. Here we …

… sugar modifications nor methylations are incorporated in the cytidines of the two CpG motifs.
Therefore, sugar modification … showing that 2′-OMe modification of two bases preceding a …

… The third strand oligonucleotide must be nuclease resistant, … Base and sugar modifications
that address these issues have … modified nucleosides incorporated into the oligonucleotides …

… This is, in part, due to the enhanced biophysical properties of second generation antisense
oligonucleotides. 2'-Modifications that influence the sugar to adopt a 3'-endo sugar pucker …

… Hybridization properties of these modified oligonucleotides with the corresponding natural
… with serinolmodified oligonucleotides was made. Stability of the modified oligomers against …

… are introduced into the antisense oligonucleotides (AON), the modified AON binds to the …
as by the endocyclic sugar torsions and the orientation of the base relative to the sugar (Figure 1…