Survite: Learning heterogeneous treatment effects from time-to-event data

A Curth, C Lee… - Advances in Neural …, 2021 - proceedings.neurips.cc
Advances in Neural Information Processing Systems, 2021proceedings.neurips.cc
We study the problem of inferring heterogeneous treatment effects from time-to-event data.
While both the related problems of (i) estimating treatment effects for binary or continuous
outcomes and (ii) predicting survival outcomes have been well studied in the recent
machine learning literature, their combination--albeit of high practical relevance--has
received considerably less attention. With the ultimate goal of reliably estimating the effects
of treatments on instantaneous risk and survival probabilities, we focus on the problem of …
Abstract
We study the problem of inferring heterogeneous treatment effects from time-to-event data. While both the related problems of (i) estimating treatment effects for binary or continuous outcomes and (ii) predicting survival outcomes have been well studied in the recent machine learning literature, their combination--albeit of high practical relevance--has received considerably less attention. With the ultimate goal of reliably estimating the effects of treatments on instantaneous risk and survival probabilities, we focus on the problem of learning (discrete-time) treatment-specific conditional hazard functions. We find that unique challenges arise in this context due to a variety of covariate shift issues that go beyond a mere combination of well-studied confounding and censoring biases. We theoretically analyse their effects by adapting recent generalization bounds from domain adaptation and treatment effect estimation to our setting and discuss implications for model design. We use the resulting insights to propose a novel deep learning method for treatment-specific hazard estimation based on balancing representations. We investigate performance across a range of experimental settings and empirically confirm that our method outperforms baselines by addressing covariate shifts from various sources.
proceedings.neurips.cc
以上显示的是最相近的搜索结果。 查看全部搜索结果