Two different sustainable and efficient synthetic methods have been developed for the synthesis of a variety of 3‐aminoimidazo fused heterocycles by one‐pot three component reaction of 2‐aminoazines, aldehydes and isocyanides. The methods adopted were (a) aqueous micellar mediated condition (method A) (b) VB₁ catalyzed reaction under solvent‐free condition (method B). Excellent yields were obtained for a broad range of biologically significant imidazopyridine core molecules under green conditions at room temperature. Synthesis in aqueous micellar medium, mild reaction conditions, organocatalyst, easy work‐up and isolation, and gram scale synthesis, are some of the advantages of these protocols.