… These findings raise the possibility that presynaptic dysfunction might be an early component
of synaptic dysfunction in Alzheimer’s disease, and that presenilins can affect synapses via …

… loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) …
protein pathologies, the synapse itself may also be a critical endpoint to consider regarding …

… Based on the evidence discussed here, we postulate that AD begins as a disease of synaptic
dysfunction and synapse loss then progresses to include widespread neuronal loss and …

… synaptic dysfunction, although the long presymptomatic phase of the human disease means
that both synaptic … revealed significant deficits in basal synaptic transmission and/or long-…

… ► Alzheimer’s disease is the result of synaptic dysfunction and neuronal loss. ► Mouse
models of AD recapitulate the synaptic dysfunction phenotype. ► Memory deficits are …

… A surprising aspect of synaptic loss in Alzheimer's disease is that it is associated only with
… at the synaptic level. As determined by confocal laser imaging the number of synapses per …

… of neurons and degeneration of synapses, causes the debilitating dementia associated
with Alzheimer’s disease (AD). We suggest that synaptic changes are central to the disease …

… we now call synapses [151] and Alzheimer … synapses were lost or damaged in Alzheimer’s
disease (AD) was first reported in the 1980s and since then studies have shown that synapse …

… with Alzheimer’s Disease (AD) is unknown. To approach this question, we studied synaptic
… proteins found in synaptic +rmi@s-synapsin I and synaptophysin-as synaptic markers in the …

… Since synaptic density correlates more closely with cognitive impairment than any other …
in the disease pathology, an increased understanding of the mechanisms behind synaptic …