Synthesis, Characterization and In Vitro Anticancer Activity of C‐5 Curcumin Analogues with Potential to Inhibit TNF‐α‐Induced NF‐κB Activation
A Anthwal, BK Thakur, MSM Rawat… - BioMed research …, 2014 - Wiley Online Library
BioMed research international, 2014•Wiley Online Library
In a search of new compounds active against cancer, synthesis of a series of C‐5 curcumin
analogues was carried out. The new compounds demonstrated good cytotoxicity against
chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these
compounds were found to have better potential to inhibit TNF‐α‐induced NF‐κB activation in
comparison to curcumin, which show their potential to act as anti‐inflammatory agents.
Some compounds were found to show higher cytotoxicity against cancer cell lines in …
analogues was carried out. The new compounds demonstrated good cytotoxicity against
chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these
compounds were found to have better potential to inhibit TNF‐α‐induced NF‐κB activation in
comparison to curcumin, which show their potential to act as anti‐inflammatory agents.
Some compounds were found to show higher cytotoxicity against cancer cell lines in …
In a search of new compounds active against cancer, synthesis of a series of C‐5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF‐α‐induced NF‐κB activation in comparison to curcumin, which show their potential to act as anti‐inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.
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