… –activity relationship studies were carried out using derivatives based on pyripyropene A
(PPPA… We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl …

… In an effort to develop potent and selective inhibitors toward ACAT2, structure–activity
relationship studies were carried out using derivatives based on pyripyropene A (PPPA, 1). In …

32 C28H33O7N 496.2346(M+ H) 35 C29H37O7N 512.2650 (M+ H) 17 C30H39O7N
526.2808(M+ H) 21 C27H33O8N 500.2310 (M+ H) 83 C32H35O7N 546.2500(M+ H) 85 …

… Structure-activity relationships of the pyridine-pyrone moiety in pyripyropene A(1), a potent
acyl-CoA : cholesterol acyltransferase (ACAT)inhibitor of fungal origin, were studied. Several …

… Synthesis and structure–activity relationships of 7-O-p-cyanobenzoyl pyripyropene A
derivatives with modification at C1 and 11 are described. Regioselective mono-deprotection …

… of pyripyropenes have … )activity in vitro and to lower cholesterol absorption in vivo in a
cholesterol-fed hamster. 7-0-«-Valeryl derivative (8c) improved the in vitro ACATinhibitory activity (…

… , 13k showed moderate tickicidal activity through contact application. The structure and activity
relationship (SAR) appeared to be different from that for insecticidal activity. Therefore, we …

… synthesized based on total synthesis, and the results of structure–activity relationship studies
of pyripyropene A… Among the analogues, two A-ring simplified pyripyropene A analogues …

… activity [16]. We investigated the structure–activity relationship (SAR) of these PP derivatives
… aphids, superior to that of derivative 1, taking systemic activity into consideration. In the …

… activity. Based on the structure-activity relationships described above, we propose here the
binding model of the most potent derivative PR-109 (Tg) to ACAT (Fig. 1). The phenyl group …