Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone
M Palomba, E Scarcella, L Sancineto… - European Journal of …, 2019 - Wiley Online Library
European Journal of Organic Chemistry, 2019•Wiley Online Library
An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl
selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room temperature is
described. The method provides a domino access to new spirooxindole 2, 2‐disubstituted
oxetanes in moderate to good yields under mild reaction conditions.
selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room temperature is
described. The method provides a domino access to new spirooxindole 2, 2‐disubstituted
oxetanes in moderate to good yields under mild reaction conditions.
An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room temperature is described. The method provides a domino access to new spirooxindole 2,2‐disubstituted oxetanes in moderate to good yields under mild reaction conditions.
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