[PDF][PDF] Synthesis of the core/shell structure of polycaprolactone@ curcumin-gluten for drug delivery applications
M RAMI, S Forouzandehdel, M Salami… - Bio Res Appl …, 2023 - biointerfaceresearch.com
M RAMI, S Forouzandehdel, M Salami, E Hataminejad, M Jafar
Bio Res Appl Chem, 2023•biointerfaceresearch.comIn this study, polycaprolactone (PCL) nanoparticles were effectively synthesized as novel
drug delivery systems by the electrospray method. Curcumin (Cur) was selected as the
model drug with further enhanced stability of its composition with gluten (GLU). The physical-
chemical characterization, including FTIR, UV-vis, and thermal analysis of PCL@ Cur-GLU
nanocapsules, are explored. The in vitro release profiles described by Ritger–Peppas
models were also investigated, showing sustained release for 15 h after a burst release …
drug delivery systems by the electrospray method. Curcumin (Cur) was selected as the
model drug with further enhanced stability of its composition with gluten (GLU). The physical-
chemical characterization, including FTIR, UV-vis, and thermal analysis of PCL@ Cur-GLU
nanocapsules, are explored. The in vitro release profiles described by Ritger–Peppas
models were also investigated, showing sustained release for 15 h after a burst release …
Abstract
In this study, polycaprolactone (PCL) nanoparticles were effectively synthesized as novel drug delivery systems by the electrospray method. Curcumin (Cur) was selected as the model drug with further enhanced stability of its composition with gluten (GLU). The physical-chemical characterization, including FTIR, UV-vis, and thermal analysis of PCL@ Cur-GLU nanocapsules, are explored. The in vitro release profiles described by Ritger–Peppas models were also investigated, showing sustained release for 15 h after a burst release within the first five hours.
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