Systematic genetic interaction analysis identifies a transcription factor circuit required for oropharyngeal candidiasis
NV Solis, RS Wakade, VE Glazier, TL Ollinger… - MBio, 2022 - Am Soc Microbiol
Oropharyngeal candidiasis (OPC) is a common infection that complicates a wide range of
medical conditions and can cause either mild or severe disease depending on the patient.
The pathobiology of OPC shares many features with candidal biofilms of abiotic surfaces.
The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces has been
extensively characterized and involves six key transcription factors (Efg1, Ndt80, Rob1, Bcr1,
Brg1, and Tec1). To determine if the in vitro biofilm transcriptional regulatory network also …
medical conditions and can cause either mild or severe disease depending on the patient.
The pathobiology of OPC shares many features with candidal biofilms of abiotic surfaces.
The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces has been
extensively characterized and involves six key transcription factors (Efg1, Ndt80, Rob1, Bcr1,
Brg1, and Tec1). To determine if the in vitro biofilm transcriptional regulatory network also …
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