[HTML][HTML] Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas
Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-
cells in the pancreas, resulting in failure of blood glucose regulation and devastating
secondary complications. Thus, β-cells are currently the prime target for cell-replacement
and regenerative therapy. Triggering endogenous repair is a promising strategy to restore β-
cell mass and normoglycemia in diabetic patients. Potential strategies include targeting
specific β-cell subpopulations to increase proliferation or maturation. Alternatively …
cells in the pancreas, resulting in failure of blood glucose regulation and devastating
secondary complications. Thus, β-cells are currently the prime target for cell-replacement
and regenerative therapy. Triggering endogenous repair is a promising strategy to restore β-
cell mass and normoglycemia in diabetic patients. Potential strategies include targeting
specific β-cell subpopulations to increase proliferation or maturation. Alternatively …
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