Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we
have used a systems biology approach to identify early gene'signatures' that predicted
immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination
induced genes that regulate virus innate sensing and type I interferon production.
Computational analyses identified a gene signature, including complement protein C1qB
and eukaryotic translation initiation factor 2 alpha kinase 4—an orchestrator of the integrated …
have used a systems biology approach to identify early gene'signatures' that predicted
immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination
induced genes that regulate virus innate sensing and type I interferon production.
Computational analyses identified a gene signature, including complement protein C1qB
and eukaryotic translation initiation factor 2 alpha kinase 4—an orchestrator of the integrated …
[引用][C] Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Q Td - Nat. Immunol., 2009 - cir.nii.ac.jp
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans |
CiNii Research … Systems biology approach predicts immunogenicity of the yellow fever
vaccine in humans …
CiNii Research … Systems biology approach predicts immunogenicity of the yellow fever
vaccine in humans …
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