One of the key challenges in the analysis of gene expression data is how to relate the
expression level of individual genes to the underlying transcriptional programs and cellular
state. Here we describe T-profiler, a tool that uses the t-test to score changes in the average
activity of predefined groups of genes. The gene groups are defined based on Gene
Ontology categorization, ChIP-chip experiments, upstream matches to a consensus
transcription factor binding motif or location on the same chromosome. If desired, an iterative …

One of the key challenges in the analysis of gene expression data is how to relate the
expression level of individual genes to the underlying transcriptional programs and cellular
state. Here we describe T-profiler, a tool that uses the t-test to score changes in the average
activity of predefined groups of genes. The gene groups are defined based on Gene
Ontology categorization, ChIP-chip experiments, upstream matches to a consensus
transcription factor binding motif or location on the same chromosome. If desired, an iterative …