TIM-4 Expressed by Mucosal Dendritic Cells Plays a Critical Role in Food Antigen–Specific Th2 Differentiation and Intestinal Allergy
Background & Aims: Food allergy accounts for significant morbidity. The etiology and
immune mechanisms of food allergy, however, have remained poorly understood. In this
study, we aimed to determine the role of T-cell immunoglobulin-domain and mucin-domain
(TIM)-4, a recently identified member of cell surface molecules, in the pathogenesis of
intestinal allergy in a murine model. Methods: We report that TIM-4 as well as costimulatory
molecules were up-regulated in intestinal mucosal dendritic cells by in vitro or in vivo …
immune mechanisms of food allergy, however, have remained poorly understood. In this
study, we aimed to determine the role of T-cell immunoglobulin-domain and mucin-domain
(TIM)-4, a recently identified member of cell surface molecules, in the pathogenesis of
intestinal allergy in a murine model. Methods: We report that TIM-4 as well as costimulatory
molecules were up-regulated in intestinal mucosal dendritic cells by in vitro or in vivo …
TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy.
YPC Yang PingChang, XZ Xing Zhou, CM Berin… - 2007 - cabidigitallibrary.org
Abstract Background & Aims: Food allergy accounts for significant morbidity. The etiology
and immune mechanisms of food allergy, however, have remained poorly understood. In
this study, we aimed to determine the role of T-cell immunoglobulin-domain and
mucindomain (TIM)-4, a recently identified member of cell surface molecules, in the
pathogenesis of intestinal allergy in a mutine model. Methods: We report that TIM-4 as well
as costimulatory molecules were upregulated in intestinal mucosal dendritic cells by in vitro …
and immune mechanisms of food allergy, however, have remained poorly understood. In
this study, we aimed to determine the role of T-cell immunoglobulin-domain and
mucindomain (TIM)-4, a recently identified member of cell surface molecules, in the
pathogenesis of intestinal allergy in a mutine model. Methods: We report that TIM-4 as well
as costimulatory molecules were upregulated in intestinal mucosal dendritic cells by in vitro …
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