… of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible …
in CA1. Cell cycle- and immunity-related genes are upregulated while learning- and neuronal …

… neurons of the adult forebrain reduced H4K12 acetylation and the dysregulation of gene
expression in the hippocampal CA1 … , we did not obtain any viable Tip60 cKO animals after birth, …

… chromatin regulators that mediate the induction of neuronal cell fate. We found that Tip60
acetyltransferase is essential to establish neuronal cell identity partly via acetylation of the …

… Coordinated and dynamic transcriptional responses in neurons affecting the neuroplasticity
… to be required for the transcriptional regulation of genes enriched for neuronal function and …

… It consists of 16 subunits of which Ep400 and Tip60/Kat5 are the main catalytic and name
giving ones (Figure 8). Furthermore, Ep400 represents the central structural subunit of the …

… Considering the profound senescence of adult CMs, it has been speculated that the attainment
of bona fide CM proliferation sufficient to re-muscularize the myocardium may require the …

… TIP60 is required for neuronal viability, and TIP60-deficiency leads to extensive
neurodegeneration in the hippocampus (… in synaptic plasticity at the CA3-CA1 area of the …

… of CA1/CA3 pyramidal neurons and DG granule neurons in a … Gcn5/KAT2A, Tip60/KAT5, and
MOF/KAT8, which are expressed in … , is required for neuronal viability 47 further supports an …

… Regulation of the acetylated state of K389 in ZIKV NS3 modulates RNA binding and unwinding
and is required for … TIP60/KAT5 is required for neuronal viability in hippocampal CA1. …

… by Aβ oligomers in rat CA1 pyramidal neurons (Krishna et al., 2016). Selective inhibition
by specific HDACi can reduce the side effects and serves as a viable therapeutic strategy. An …