The role of TLR2 in infection and immunity

L Oliveira-Nascimento, P Massari… - Frontiers in …, 2012 - frontiersin.org
TLR2 forms heterodimers with TLR1 and TLR6, which is the … This review will discuss the
current status of TLR2 mediated … non-canonical responses to TLR2 ligands with emphasis on …

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors

J van Bergenhenegouwen, TS Plantinga… - Journal of leukocyte …, 2013 - academic.oup.com
… A breadth of data has been published on ligand-induced interactions of TLR2 with … all of
them important factors in TLR2 function. This review summarizes the roles of TLR2 in vivo and in …

The function of TLR2 during staphylococcal diseases

B Fournier - Frontiers in cellular and infection microbiology, 2013 - frontiersin.org
… of staphylococcal lipoproteins in TLR2 recognition. A new … be efficiently detected by the
TLR2 of professional phagocytes. … will therefore describe the role of TLR2 in PMN recruitment in …

TLR2 is expressed on activated T cells as a costimulatory receptor

M Komai-Koma, L Jones, GS Ogg… - Proceedings of the …, 2004 - National Acad Sciences
… levels of cell-surface TLR2 after activation by anti… TLR2 ligand, bacterial lipopeptide.
Furthermore, CD4 + CD45RO + memory T cells from peripheral blood constitutively expressed TLR2

[HTML][HTML] TLR2–promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

U Zähringer, B Lindner, S Inamura, H Heine… - Immunobiology, 2008 - Elsevier
… agonists of TLR2 we have chosen Staphylococcus aureus to investigate TLR2 PAMPs because
it … In this review, we concentrate exclusively on TLR2 and its agonist isolated from Gram-…

TLR2 and TLR4 in autoimmune diseases: a comprehensive review

Y Liu, H Yin, M Zhao, Q Lu - Clinical reviews in allergy & immunology, 2014 - Springer
… studies reveal that cell surface TLRs, especially TLR2 and TLR4, also play an essential role
… of TLR2/4, the negative regulators of TLR2/4 pathway, and the pivotal function of TLR2/4 in …

Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling

JK Gautam, LD Comeau, JK Krueger… - Journal of Biological …, 2006 - ASBMB
… of TLR2 we performed a random mutagenesis analysis of the human TLR2 TIR domain and
screened for TLR2… an alanine scanning mutagenesis of the TLR2 DD loop and part of the αD …

[HTML][HTML] Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

O Takeuchi, K Hoshino, T Kawai, H Sanjo, H Takada… - Immunity, 1999 - cell.com
… To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS …
that the TLR2 mutation inactivates the TLR2 gene, we performed Northern blot analysis. TLR2

TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review

S Mukherjee, S Karmakar, SPS Babu - Brazilian Journal of Infectious …, 2016 - SciELO Brasil
TLR2 and TLR4 have gained immense importance due to … and immunopathological attributes
of TLR2 and TLR4 mediated … Thus, stimulation of host immune response with TLR2 and …

TLR2 and TLR4 in ischemia reperfusion injury

F Arslan, B Keogh, P McGuirk… - Mediators of …, 2010 - Wiley Online Library
… In this paper, we summarise the current state of knowledge linking TLR2 and TLR4 to I/R
injury, including recent studies which demonstrate that therapeutic inhibition of TLR2 has …