… small peptide-inhibitors of the TLR4/MD2−LPS interaction. Here we report novel TLR4-antagonistic
peptides (TAP), identified through phage display, endowed with the LPS-induced …

… Considering that small peptides are more convenient to … peptides that halt the LPS
induced TLR4 pathway. The selected TLR4-antagonizing peptides (TAPs) suppress the LPS-induced …

… for the LPS-TLR4/MD2 and three different peptide-TLR4/MD2 interaction pairs (Table 2). …
TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation. Biomaterials…

… TLR4/MD2/Peptide-2 and TLR4/MD2 complexes (Table 3). … the specific mechanisms obtained
in our preliminary in vitro … positive effects of Peptide-2 against LPS-induced cell viability, …

… suggested that PIP2 significantly stalled both arms of the … and TLR4/MD2 heterodimer, we
docked PIP2 with TLR4/MD2 … of cPIP2 on LPS-induced inflammatory response in vitro, we …

… in the inflammatory response and immune regulation. In the … In the present study, LPS, a
TLR4/MD2 ligand, activated the reporter … LPS-induced TLR4 signaling in vivo and in vitro [26]. …

… These peptides are thought to decrease LPS-induced TLR4 … inflammation through modifying
immunological responses in … bronchial neutrophilia and asthma exacerbation. Given that …

… Collectively, our biophysical, in vitro, and in vivo findings suggest … Design of the peptides
and in vitro screening. (A) The … in the model of an LPS-induced sepsis. For survival efficiency …

… Figure 2 The in vitro immunomodulatory activity of the hybrid peptides in RAW264.7 cells. …
In addition to these general immune parameters, antigen-specific immune response …

… showed that papiliocin inhibited LPS-induced TLR4 signaling by … features of papiliocin
required for its binding to TLR4/MD2. … to determine the in vivo toxicities of peptides (SI Appendix). …