TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury

JM Rosa, V Farré‐Alins, MC Ortega… - British journal of …, 2021 - Wiley Online Library
… TBI seems to regulate the synaptic recovery in the sub-… astrocyte activation through inhibition
of TLR4 pathway in inflammatory cells plays an important role in the regulation of synapses

Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons

Y Shen, H Qin, J Chen, L Mou, Y He, Y Yan… - Journal of Cell …, 2016 - rupress.org
activation impairing astrocyte functions may strongly affect the development of a specific type
of synapse… recruited after TLR4 activation in astrocytes and regulates synapse development…

[PDF][PDF] TLR4-pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury

M Rosa Juliana, E Javier - researchgate.net
… TBI seems to regulate the synaptic recovery in the sub… astrocyte activation through inhibition
of TLR4-pathway in inflammatory cells plays an important role in the regulation of synapses

TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer's disease

J Yang, L Wise, K Fukuchi - Frontiers in immunology, 2020 - frontiersin.org
… contributes to insulin resistance by impairing insulin signal … deficiency decreases microglial
activation and cerebral Aβ load … microglia induce A1 astrocytes by releasing TNFα, IL-1α, and …

Vascular cognitive impairment caused by cerebral small vessel disease is associated with the TLR4 in the hippocampus

F Gao, Y Jing, P Zang, X Hu, C Gu… - Journal of …, 2019 - content.iospress.com
… The number of positive cells of TLR4, active astrocyte and … lesions cause or contribute to
impaired cognitive function. Within … speculate that TLR4 is involved in the activation of glial cells. …

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles

F Ibáñez, J Montesinos, JR Ureña-Peralta… - Journal of …, 2019 - Springer
… ethanol activates glial cells through Toll-like receptor 4 (TLR4… regulating the extracellular
environment, cerebral blood flow, … by cortical neurons, which affects the physiological state of …

The role of TLR4 and Fyn interaction on lipopolysaccharide-stimulated PAI-1 expression in astrocytes

HM Ko, SH Lee, KC Kim, SH Joo, WS Choi… - Molecular …, 2015 - Springer
TLR4 KO mice showed smaller cerebral infarctions due to … immune activation, as well as
their role in astrocyte activation … stroke where neurite elongation and regeneration is impaired. …

Toll-like receptor 4 signaling in focal cerebral ischemia: a focus on the neurovascular unit

BM Famakin, R Vemuganti - Molecular neurobiology, 2020 - Springer
… In this review, we examined the activation of TLR4 in neuronal, glial, … by astrocyte-neuronal
signaling, is also impaired following … TLR4 expression and signaling in penumbral astrocytes

Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus

Y Zhang, Y Zhang, R Wu, F Gao, P Zang, X Hu… - Journal of Clinical …, 2019 - Elsevier
… Based on these results, we suggest that TLR4 affects the cognitive function of CSVD rats, …
, and TLR4 can activate the microglia and astrocytes that activate the neuroinflammatory …

Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice

A Ahmad, R Crupi, M Campolo, T Genovese… - PloS one, 2013 - journals.plos.org
… the critical role of TLR4 in the neuroinflammation and cerebralsignaling in astrocytes,
since the knockdown of TLR4, by … that TLRs activate nuclear factor κ-B signaling pathways that …