TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE−/− mice
Background and aims Atherosclerosis is a major cause of heart attack and stroke.
Inflammation plays a critical role in the development of atherosclerosis. Since the
cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role
in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2
mediates atherosclerotic plaque development. Methods TRAF3IP2/ApoE double knockout
(DKO) mice were generated by crossing TRAF3IP2−/− and ApoE−/− mice. ApoE−/− mice …
Inflammation plays a critical role in the development of atherosclerosis. Since the
cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role
in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2
mediates atherosclerotic plaque development. Methods TRAF3IP2/ApoE double knockout
(DKO) mice were generated by crossing TRAF3IP2−/− and ApoE−/− mice. ApoE−/− mice …