TSPAN1: a novel protein involved in head and neck squamous cell carcinoma chemoresistance
Y Garcia-Mayea, C Mir, L Carballo, J Castellvi… - Cancers, 2020 - mdpi.com
Simple Summary Therapy resistance in head and neck squamous cell carcinoma (HNSCC)
patients is the main obstacle to achieve more effective treatments that improve survival and
quality of life of these patients. Therefore, it is of vital importance to unravel the molecular
and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We
conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem
cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin …
patients is the main obstacle to achieve more effective treatments that improve survival and
quality of life of these patients. Therefore, it is of vital importance to unravel the molecular
and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We
conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem
cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin …
TSPAN1:: a Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
J Castellvi, YG Mayea, CM Pérez, L Carballo… - …, 2020 - portalrecerca.uab.cat
Sensitization of resistant cells and cancer stem cells (CSCs) represents a major challenge in
cancer therapy. A proteomic study revealed tetraspanin-1 (TSPAN1) as a protein involved in
acquisition of cisplatin (CDDP) resistance (Data are available via ProteomeXchange with
identifier PXD020159). TSPAN1 was found to increase in CDDP-resistant cells, CSCs and
biopsies from head and neck squamous cell carcinoma (HNSCC) patients. TSPAN1
depletion in parental and CDDP-resistant HNSCC cells reduced cell proliferation, induced …
cancer therapy. A proteomic study revealed tetraspanin-1 (TSPAN1) as a protein involved in
acquisition of cisplatin (CDDP) resistance (Data are available via ProteomeXchange with
identifier PXD020159). TSPAN1 was found to increase in CDDP-resistant cells, CSCs and
biopsies from head and neck squamous cell carcinoma (HNSCC) patients. TSPAN1
depletion in parental and CDDP-resistant HNSCC cells reduced cell proliferation, induced …
以上显示的是最相近的搜索结果。 查看全部搜索结果