Ensuring precise drug release at target sites is crucial for effective treatment. Here, pH‐
responsive nanoparticles for oral administration of mycophenolate mofetil, an alternative
therapy for patients with inflammatory bowel disease unresponsive to conventional
treatments is developed. However, its oral administration presents challenges due to its low
solubility in the small intestine and high solubility and absorption in the stomach. Therefore,
this aim is to design a drug delivery system capable of maintaining drug solubility compared …

In article number 2403640, Matteo Tollemeto and co-workers aimed to design a
nanoparticle drug delivery system that maintains drug solubility while delaying absorption
from the stomach to the intestine. In vivo rat studies of pH-responsive polymersomes showed
reduced stomach absorption and enhanced intestinal absorption, offering a promising
treatment for inflammatory bowel disease.