Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells
Cardiotoxin III (CTX III), a basic polypeptide with 60-amino acid residues isolated from Naja
naja atra venom, has been reported to have cytotoxic activity. CTX III exerted cytotoxicity with
the S-phase cell cycle arrest, correlated with a marked decrease in the expression levels of
cyclin A, cyclin B, and cyclin-dependent kinase 1 (CDK1), and apoptosis, accompanied with
Bax and Bad up-regulation, and the down-regulation of Bcl-2, p-Bad, and X-linked inhibitor
of apoptosis (XIAP) with cytochrome c release and sequential activation of caspase-9 and …
naja atra venom, has been reported to have cytotoxic activity. CTX III exerted cytotoxicity with
the S-phase cell cycle arrest, correlated with a marked decrease in the expression levels of
cyclin A, cyclin B, and cyclin-dependent kinase 1 (CDK1), and apoptosis, accompanied with
Bax and Bad up-regulation, and the down-regulation of Bcl-2, p-Bad, and X-linked inhibitor
of apoptosis (XIAP) with cytochrome c release and sequential activation of caspase-9 and …
Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells.
CCM Chien ChingMing, CSY Chang ShangYu… - 2010 - cabidigitallibrary.org
Abstract Cardiotoxin III (CTX III), a basic polypeptide with 60-amino acid residues isolated
from Naja naja atra venom, has been reported to have cytotoxic activity. CTX III exerted
cytotoxicity with the S-phase cell cycle arrest, correlated with a marked decrease in the
expression levels of cyclin A, cyclin B, and cyclin-dependent kinase 1 (CDK1), and
apoptosis, accompanied with Bax and Bad up-regulation, and the down-regulation of Bcl-2,
p-Bad, and X-linked inhibitor of apoptosis (XIAP) with cytochrome c release and sequential …
from Naja naja atra venom, has been reported to have cytotoxic activity. CTX III exerted
cytotoxicity with the S-phase cell cycle arrest, correlated with a marked decrease in the
expression levels of cyclin A, cyclin B, and cyclin-dependent kinase 1 (CDK1), and
apoptosis, accompanied with Bax and Bad up-regulation, and the down-regulation of Bcl-2,
p-Bad, and X-linked inhibitor of apoptosis (XIAP) with cytochrome c release and sequential …
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