Tamoxifen/montmorillonite as a controlled release oral system
DTC Silva, IES Arruda, JIR de Araújo… - Journal of Drug Delivery …, 2023 - Elsevier
Drugs have been incorporated into clay minerals to obtain a controlled-release system. In
the present study, tamoxifen citrate (TMX) was loaded in pharmaceutical montmorillonite
(VHS) at pH 3.0, 4.0, and 5.0 and released in vitro under simulated stomach and intestinal
conditions to evaluate the cytotoxic activity of TMX/VHS systems. The systems were
characterized using structural (X-ray diffractometry and Fourier transform infrared
spectroscopy) and thermal (thermogravimetric analysis and differential calorimetry) …
the present study, tamoxifen citrate (TMX) was loaded in pharmaceutical montmorillonite
(VHS) at pH 3.0, 4.0, and 5.0 and released in vitro under simulated stomach and intestinal
conditions to evaluate the cytotoxic activity of TMX/VHS systems. The systems were
characterized using structural (X-ray diffractometry and Fourier transform infrared
spectroscopy) and thermal (thermogravimetric analysis and differential calorimetry) …
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