Targeted sequencing of plasma-derived vs. urinary cfDNA from patients with triple-negative breast cancer
H Herzog, S Dogan, B Aktas, I Nel - Cancers, 2022 - mdpi.com
Simple Summary Circulating cell-free DNA displays vast potential to capture the entire
genetic landscape of a tumor and to characterize intratumoral heterogeneity, providing a
minimally invasive alternative to tissue biopsy. Several studies have demonstrated the
potential of cell-free DNA in the plasma of breast cancer patients. In contrast, very little is
known about the utility of urine as an even more patient-convenient analyte for these
applications. In this pilot study, we investigated plasma-derived and matching urinary cell …
genetic landscape of a tumor and to characterize intratumoral heterogeneity, providing a
minimally invasive alternative to tissue biopsy. Several studies have demonstrated the
potential of cell-free DNA in the plasma of breast cancer patients. In contrast, very little is
known about the utility of urine as an even more patient-convenient analyte for these
applications. In this pilot study, we investigated plasma-derived and matching urinary cell …