Targeting PIM1-mediated metabolism in myeloid suppressor cells to treat cancer
There is a strong correlation between myeloid-derived suppressor cells (MDSC) and
resistance to immune checkpoint blockade (ICB), but the detailed mechanisms underlying
this correlation are largely unknown. Using single-cell RNA sequencing analysis in a
bilateral tumor model, we found that immunosuppressive myeloid cells with characteristics of
fatty acid oxidative metabolism dominate the immune-cell landscape in ICB-resistant
subjects. In addition, we uncovered a previously underappreciated role of a serine/threonine …
resistance to immune checkpoint blockade (ICB), but the detailed mechanisms underlying
this correlation are largely unknown. Using single-cell RNA sequencing analysis in a
bilateral tumor model, we found that immunosuppressive myeloid cells with characteristics of
fatty acid oxidative metabolism dominate the immune-cell landscape in ICB-resistant
subjects. In addition, we uncovered a previously underappreciated role of a serine/threonine …
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