… novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery …
Transduction efficiencies of self-complimentary, capsid-mutant and unmodified AAV vectors …

… Seventy-two hours post transfection, purification of AAV vector … using a minimally invasive
intravitreal delivery technique, wherein a small volume of undiluted capsid mutant virus vector …

… Notably, both intravitreal and subretinal delivery of AAV vectors … capsids for specific targeting
of AAV vectors. The interaction … in photoreceptors from an AAV5 and an AAV2-HBKO vector, …

… intravitreal injection of vector and more efficient targeting of inner retinal cells to introduce
novel … An alternative approach is to target the photoreceptors and RPE via intravitreal injection. …

… of novel AAV vectors to transduce photoreceptors in dogs following IVT. We found both IRBP
… Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors. …

… Consequently, when treatment is targeted to cone photoreceptors, the vector should be
injected in the central and most sensitive part of the retina, namely macular/foveal area. Third, …

… epithelium and photoreceptors are efficiently targeted by various AAV serotypes following
delivery to the subretinal space. RGCs are efficiently transduced following vitreal delivery (38,…

… Intraocular injection of purified recombination ciliary … applied in clinical trials to target
photoreceptors (rods and cones) [… shows that those 2 novel AAV variants can efficiently target …

… to AAV development in the context of intricate intraocular spaces… for photoreceptors compared
to AAVs. For these reasons, … yield a toolbox of AAV vectors capable of targeting each of the …

… While delivering AAV in situ to photoreceptors and RPE via subretinal injection leads to efficient
transduction of these cells, it is not a suitable route for targeting … of our novel AAV capsid …