Pancreatic cancer is a highly lethal disease. Conventional therapeutics targeting pancreas
cancer cell compartment using cytotoxics improved patient survival but at the expense of
significant toxicity. Microscopically, the tumor is characterized by thick desmoplastic stroma
that surrounds islands of pancreatic cancer cells. The tumor microenvironment has been
found to play important roles in carcinogenesis, the development of drug resistance, and
mediating immunosuppression. The understanding the tumor-stromal interaction has led to …