Simple Summary Therapeutic targeting of Wnt has long been suggested for gastrointestinal
(GI) cancer treatment because deregulation of Wnt signaling is associated with GI cancers.
However, therapeutic targeting of Wnt is still challenging because of the pleiotropic roles of
Wnt signaling in the human body. Thus, targeting strategies of Wnt signaling are
continuously evolving. The current flows of targeting Wnt signaling for cancer treatment are
focused on increasing the specificity of drugs and combinatory treatment with other cancer …