Taxonomy meets neurology, the case of amyotrophic lateral sclerosis
Frontiers in Neuroscience, 2018•frontiersin.org
Recent landmark publications from our research group outline a transformative approach to
defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching
ALS as a single entity, we advocate targeting therapies to distinct “clusters” of patients based
on their specific genomic and molecular features. Our findings point to the existence of a
molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision
medicine approach in neurology practice.
defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching
ALS as a single entity, we advocate targeting therapies to distinct “clusters” of patients based
on their specific genomic and molecular features. Our findings point to the existence of a
molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision
medicine approach in neurology practice.
Recent landmark publications from our research group outline a transformative approach to defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching ALS as a single entity, we advocate targeting therapies to distinct “clusters” of patients based on their specific genomic and molecular features. Our findings point to the existence of a molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision medicine approach in neurology practice.
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