Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells
Polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder associated with
insulin resistance. Insulin exerts its metabolic function by activating the PI3K/Akt pathway
and favoring glucose uptake. Caveolin-1 is a scaffolding protein which increases insulin
receptor (IR) stability. Alternatively, activation of IR increases caveolin-1 phosphorylation on
tyrosine-14. Furthermore, endometrial tissue from PCOS patients is proposed to be insulin
resistant; however, the particular role of testosterone in modulating the metabolic effects of …
insulin resistance. Insulin exerts its metabolic function by activating the PI3K/Akt pathway
and favoring glucose uptake. Caveolin-1 is a scaffolding protein which increases insulin
receptor (IR) stability. Alternatively, activation of IR increases caveolin-1 phosphorylation on
tyrosine-14. Furthermore, endometrial tissue from PCOS patients is proposed to be insulin
resistant; however, the particular role of testosterone in modulating the metabolic effects of …
Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells
Polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder associated with
insulin resistance. Insulin exerts its metabolic function by activating the PI3K/Akt pathway
and favoring glucose uptake. Caveolin-1 is a scaffolding protein which increases insulin
receptor (IR) stability. Alternatively, activation of IR increases caveolin-1 phosphorylation on
tyrosine-14. Furthermore, endometrial tissue from PCOS patients is proposed to be insulin
resistant; however, the particular role of testosterone in modulating the metabolic effects of …
insulin resistance. Insulin exerts its metabolic function by activating the PI3K/Akt pathway
and favoring glucose uptake. Caveolin-1 is a scaffolding protein which increases insulin
receptor (IR) stability. Alternatively, activation of IR increases caveolin-1 phosphorylation on
tyrosine-14. Furthermore, endometrial tissue from PCOS patients is proposed to be insulin
resistant; however, the particular role of testosterone in modulating the metabolic effects of …