Tetrazine‐responsive self‐immolative linkers
K Neumann, S Jain, A Gambardella, SE Walker… - …, 2017 - Wiley Online Library
ChemBioChem, 2017•Wiley Online Library
Molecules that undergo activation or modulation following the addition of benign external
small‐molecule chemical stimuli have numerous applications. Here, we report the highly
efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by
application of water‐soluble and stable tetrazine, including the controlled delivery of
doxorubicin in a cellular context.
small‐molecule chemical stimuli have numerous applications. Here, we report the highly
efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by
application of water‐soluble and stable tetrazine, including the controlled delivery of
doxorubicin in a cellular context.
Abstract
Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.
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